{"id":14673,"date":"2022-02-08T13:24:46","date_gmt":"2022-02-08T18:24:46","guid":{"rendered":"https:\/\/www.technoparc.com\/blogue-modelis\/"},"modified":"2022-02-09T08:47:13","modified_gmt":"2022-02-09T13:47:13","slug":"blog-modelis","status":"publish","type":"post","link":"https:\/\/technoparc.com\/en\/blog-modelis\/","title":{"rendered":"Searching for cures, where and how no one is looking"},"content":{"rendered":"[et_pb_section fb_built=”1″ _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.12.1″ _module_preset=”default” background_color=”#d6d6d6″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”]\n

Imagine being diagnosed with a rare genetic disease and finding out there\u2019s no treatment available. This is the case for hundreds of millions of people worldwide. The truth is 7,000 rare diseases affect more than 700 million people globally, but only 5% have an approved cure or therapy.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”]\n

The high upfront costs of traditional drug discovery combined with small patient sizes, have resulted in rare diseases being neglected by the pharmaceutical industry. Using a classical drug discovery approach to find rare-disease cures just isn\u2019t practical or feasible for many different reasons, and this is where Modelis<\/a> comes in.<\/p>\n

Founded in July 2018, Modelis is building a drug discovery platform that uses data, artificial intelligence (AI), machine learning (ML), and small animal models to identify new drug candidates and repurpose proven treatments for rare and complex disorders with unmet needs.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/technoparc.com\/wp-content\/uploads\/2022\/02\/photo-james-doyle.jpg” title_text=”Photo James Doyle” _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_testimonial author=”James Doyle” job_title=”Chief executive officer and co-founder” company_name=”Modelis” _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”]\n

\u201cWe like to say we do drug discovery differently. Drug discovery requires deep knowledge of a disease\u2019s pathology before being able to start any therapeutic discovery journey. This process can then cost millions of dollars and take up to 10 years before a drug can even begin being tested in humans. In the market for rare-disease drugs, there\u2019s no time or money for that, so we decided to turn this drug discovery model on its head.\u201d<\/p>\n[\/et_pb_testimonial][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”]\n

Speeding up the process<\/strong><\/h2>\n

Modelis\u2019 approach accelerates the early stages in the drug discovery and development process. First, using data and AI, they rapidly evaluate the relevance of potential targets and pathways to the pathology of a disease, a necessary but traditionally rate-limiting step in the process. They then use simple animal models (such as worms and fish) to confirm their viability as therapeutic targets, and test the efficacy of potential therapies, developing more data and insights as they go.<\/p>\n

\u201cWe use simple animal models because eighty percent of the genes causing human diseases are evolutionarily conserved in small animals like worms and fish,\u201d Doyle says. \u201cThis means we can leverage these similarities to study complex disorders in simple vessels and develop new therapies\u2014or repurpose existing treatments\u2014in fast, cost-friendly ways.\u201d<\/p>\n

 <\/p>\n[\/et_pb_text][et_pb_text _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”]\n

Therapeutic breakthroughs<\/strong><\/h2>\n

Early on, the idea of using small animals to test small molecules seemed far-fetched, but Alex Parke, co-founder of Modelis, and his colleagues decided to try anyway. They tested more than 4,000 approved compounds on sick worms, resulting in the first therapeutic breakthrough for Amyotrophic Lateral Sclerosis (ALS)\u2014a neuromuscular disease that attacks the neurons and spinal cord\u2014in 25 years.<\/p>\n

Through this research, his colleagues identified a short list of fifteen of molecules and eventually confirmed the efficacy of Pimozide (an FDA-approved therapy for schizophrenia) to treat ALS in fish and mice. This was the first example of worm-to-human drug discovery and proof of concept of Modelis\u2019 approach. This discovery resulted in a large-scale, nationwide Phase 2b trial which is now underway, examining the effect of Pimozide therapy in patients with ALS after six-month periods.<\/p>\n

 <\/p>\n[\/et_pb_text][et_pb_text _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”]\n

Bridging the gap between bench and bedside<\/strong><\/h2>\n

Modelis is currently advancing rapid-development programs to treat six rare diseases. While the company works with industry partners, their family-centric model also empowers patients and advocacy organizations to drive and champion medical research for specific diseases. They also currently have three projects<\/p>\n

backed by venture philanthropists, with a current research focus on neurological disorders. Modelis\u2019 approach, however, has broad applicability across a range of indications and diseases including developmental diseases, neurological disorders, metabolic disorders, cancer, cardiovascular disorders and aging.<\/p>\n

\u201cWe are driven by a desire to bridge the gaps between bench and bedside in our search for faster cures,\u201d says Doyle. \u201cOur platform will only get smarter over time, leading us to develop deeper understandings of disease pathology to discover new therapies and cures for those that need them most.\u201d<\/p>\n

Modelis is part of the first cohort of the adMare BioInnovations acceleration programme<\/a> and is based at Technoparc Montr\u00e9al. This programme, supported by the Government of Quebec and the Ville de Montr\u00e9al, aims to develop the province\u2019s most promising life-science start-ups.<\/p>\n[\/et_pb_text][et_pb_divider show_divider=”off” _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.12.1″ _module_preset=”default” background_color=”#d6d6d6″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”]\n

Discover the Technoparc’s companies<\/h2>\n[\/et_pb_text][et_pb_button button_url=”https:\/\/technoparc.com\/en\/our-companies\/” button_text=”Our companies” button_alignment=”center” module_class=”boutonrouge” _builder_version=”4.12.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

Imagine being diagnosed with a rare genetic disease and finding out there\u2019s no treatment available. This is the case for hundreds of millions of people worldwide. The truth is 7,000 rare diseases affect more than 700 million people globally, but only 5% have an approved cure or therapy.The high upfront costs of traditional drug discovery […]<\/p>\n","protected":false},"author":7,"featured_media":14666,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[34],"tags":[],"class_list":["post-14673","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-article-en"],"acf":[],"yoast_head":"\nSearching for cures, where and how no one is looking - Technoparc Montr\u00e9al<\/title>\n<meta name=\"description\" content=\"Modelis is a biotechnology company based at adMare Bionnovations that works on treatments for rare genetic diseases.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/technoparc.com\/en\/blog-modelis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Searching for cures, where and how no one is looking - 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